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Fig. 6 | Annals of Microbiology

Fig. 6

From: Salmonella enterica serovar Typhi genomic regions involved in low pH resistance and in invasion and replication in human macrophages

Fig. 6

Genomic regions involved in pH resistance are also involved in S. Typhi invasion, replication, and survival inside human macrophages. THP-1 cells were infected with S. Typhi IMSS-1 (wt), S. Typhi ΔF4 (ΔF4), S. Typhi ΔF44 (ΔF44), and S. Typhi ΔF73 (ΔF73). The viable intracellular bacteria (CFU ml−1) were determined at 2-h post-infection to evaluate invasion (a) and after 16 h to determine replication and survival inside macrophages (b). Mean±standard deviation is presented. The Hedges’s g (Hedges 1981) effect size was calculated using the esc package in Rstudio (c) and Cohen’s rule of thumb. Hedges’s values of 0.2 indicate small effect, 0.5 indicate medium effect, and 0.8 indicate large effect, shows a large difference between the ability of the wild-type versus the mutant strains to invade and replicate inside macrophages

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