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Table 2 Bioactive compounds produced by the Bacillus species and its health benefits

From: Impact of Bacillus in fermented soybean foods on human health

Microorganisms Bioactive compounds Health benefits References
Bacillus species Poly-γ-glutamic acid Suppression in the elevation of post prandial blood glucose level Chettri et al. (2016)
Bacillus species Isoflavone aglycone Flavonoid bioconversion Kim et al. (2018)
Bacillus species LM7 Bacillomycin D and surfactin Antimicrobial activity Lee et al. (2016a, 2016b)
Bacillus subtilis var. natto Nattokinase and serine protease subtilisin Fibrinolytic activity and tissue plasminogen activator can be increased Mohanasrinivasan et al. (2017)
Bacillus subtilis 1423 Protease Breaks down the complex protein to simpler molecules Nguyen and Nguyen (2020)
Bacillus subtilis DC27 Serine protease Fibrinolytic activity Hu et al. (2019)
Bacillus subtilis natto O9516 ACE inhibitory peptides Anti-hypertensive activity Ibe et al. (2009)
Bacillus subtilis Nattokinase Anti-hyperlipidemic activity Chen et al. (2018)
Bacillus natto TK-1 Lipopeptide Biosurfactant activity Cao et al. (2009)
Bacillus subtilis Protease and esterase Degradation of proteins and fats Sanjukta and Rai (2016)
Bacillus subtilis Proteolytic enzymes Glycinin and β -conglycinin hydrolyzed for the production of bioactive peptides Sanjukta and Rai (2016)
Bacillus subtilis var. natto PGA and fructan (mucilage) Antioxidant properties Chettri and Tamang (2014)
Bacillus subtilis SN7 Bacteriocin Biocontrol agent Lee and Chang (2017)
Bacillus subtilis CSY 191 Surfactin Inhibits growth of human breast cancer cells (MCF-7) Lee et al. (2012)
Bacillus subtilis (natto) Lipoproteins Anti-inflammatory response Rhayat et al. (2019)
Bacillus subtilis SHZ Bioactive peptide and polyphenols Antioxidant activity Sanjukta and Rai (2016)
Bacillus subtilis N205 (BS205) Isoflavone aglycones Antioxidant properties Ping et al. (2012)
Bacillus subtilis-SKm (BS-c) α-amylase, and γ-GTP Antioxidant property Zheng et al. (2011)
Bacillus subtilis SC-8 Surfactin, fengycin and iturin. Antifungal and antibiotic properties Yeo et al. (2011a, 2011b)
Bacillus subtilis NT-6 Amphipathic peptide AMPNT-6 Antimicrobial effect Xu et al. (2013)
Bacillus subtilis SCK-2 Peptide AMPC IC-1 Antimicrobial properties Yeo et al. (2011a, 2011b)
Bacillus amyloliquefaciens FZB42 Fibrinolytic enzymes Fibrinolytic activity Huy et al. (2016)
Bacillus amyloliquefacians EMD 17 Surfactin Antimicrobial activity Lee et al. (2016a, 2016b)
Bacillus amyloliquefacians Daidzein Anti-diabetic property Jeong et al. (2020)
Bacillus amyloliquefacians 1-Deoxynojirimycin Alpha-glucosidase inhibitor Cai et al. (2017)
Bacillus amyloliquefaciens SWJS22 β-glucosidase and protease Antioxidant activity Yang et al. (2019a, 2019b)
Bacillus amyloliquefaciens RWL-1 Isoflavones and phenolic contents Antioxidant properties Shahzad et al. (2020)
Bacillus amyloliquefaciens Genistein Neuroprotective effect Khosravi and Razavi (2021)
Bacillus licheniformis B65-1 Phenylacetic acid Inhibition of enteric pathogens Kim et al. (2004)
Bacillus licheniformis 67 Poly-γ-glutamic acid Anti-obesity effect Choi et al. (2016)
Bacillus licheniformis (SFC) Isoflavones aglycones Anti-diabetic effect Yang et al. (2014)