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Table 3 Three-factors steepest ascent experiment

From: Simultaneous improvement of lincomycin A production and reduction of lincomycin B levels in Streptomyces lincolnensis using a combined medium optimization approach

Run

X1 (g/L)

X2 (g/L)

X7 (g/L)

Lincomycin A (mg/L)

Lincomycin B (%)

0

25

2

100

3536 ± 82

4.4 ± 0.2

1

15

1.2

140

3421 ± 102

5.3 ± 0.2

2

20

1.3

133

3875 ± 48

2.8 ± 0.1

3

25

1.4

126

4606 ± 101

0.8±0.1

4

30

1.5

119

3671 ± 152

2.4 ± 0.1

5

35

1.6

112

3415 ± 72

3.7 ± 0.2

6

40

1.7

105

2299 ± 96

3.6 ± 0.1

7

45

1.8

98

1029 ± 22

7.2 ± 0.3

  1. The values were obtained from three independent experiments
  2. X1 soybean powder, X2 corn steep liquor, X3 NaCl, X4 NaNO3, X5 KH2PO4, X6 (NH4)2SO4, X7 glucose, X8 CaCO3
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Annals of Microbiology

ISSN: 1869-2044

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