Table 4 Optimization of complex nitrogen sources for cell growth and lovastatin production by submerged cultivation of the parent strain and the mutant of A. terreus a
From: Production of lovastatin by a self-resistant mutant of Aspergillus terreus
Nitrogen sourceb | ATCC 20542 | LA4414 | ||
|---|---|---|---|---|
Biomass (g DCW l−1) | Lovastatin production (mg l−1) | Biomass (g DCW l−1) | Lovastatin production (mg l−1) | |
Yeast extract | 17.48 ± 0.32b | 165.2 ± 14.3 | 10.70 ± 0.10 | 502.5 ± 22.4 |
Peptone | 14.32 ± 0.11 | 166.4 ± 10.7 | 13.51 ± 0.22 | 278.9 ± 14.7 |
peanut | 12.65 ± 0.08 | 314.1 ± 12.4 | 10.45 ± 0.16 | 883.2 ± 19.5 |
soybean meal | 18.21 ± 0.15 | 351.5 ± 16.4 | 16.95 ± 0.27 | 352.1 ± 21.3 |
Corn steep liquor | 13.46 ± 0.05 | 257.6 ± 9.8 | 12.65 ± 0.18 | 154.3 ± 7.5 |
Oat meal | 11.34 ± 0.12 | 132.2 ± 11.4 | 8.50 ± 0.04 | 683.2 ± 18.6 |