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Table 3 Effect of S. rugosoannulata EPS on plasma glucose, total cholesterol, triglyceride levels, plasma high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, atherogenic index, plasma alanine aminotransferase, and aspartate aminotransferase in streptozotocin-induced diabetic rats for 3 weeks

From: Fermentation characteristics and hypoglycemic activity of an exopolysaccharide produced by submerged culture of Stropharia rugosoannulata #2

Parameter

Groupa

Normal

Control

L

M

H

Plasma glucose, total cholesterol, and triglyceride levels

  Glucose (mmol/L)

7.2967 ± 1.264 3a

34.7833 ± 0.8837 d

28.4533 ± 3.6187 c

25.7300 ± 1.8237 c

22.0333 ± 0.6658 b

  Total cholesterol (mmol/L)

1.8500 ± 0.0913 a

2.7150 ± 0.0742 d

2.4625 ± 0.0465 c

2.3900 ± 0.0548 c

2.0625 ± 0.0869 b

  Triglyceride (mmol/L)

0.4575 ± 0.0499 a

0.8625 ± 0.0746 d

0.7975 ± 0.0359 c,d

0.7150 ± 0.0342 b,c

0.6375 ± 0.0680 b

Plasma HDL cholesterol, and LDL cholesterol levels, and atherogenic index

  HDL cholesterol (mmol/L)

0.6825 ± 0.0222 d

0.3875 ± 0.0287 a

0.4275 ± 0.0419 a

0.5025 ± 0.0479 b

0.6000 ± 0.0356 c

  LDL cholesterolb (mmol/L)

1.0760 ± 0.1134 a

2.1550 ± 0.0673 e

1.8755 ± 0.0502 d

1.7445 ± 0.0590 c

1.3350 ± 0.0701 b

  Atherogetic Indexc

1.7100 ± 0.0510 a

6.0275 ± 0.3408 e

4.5450 ± 0.1692 d

3.8950 ± 0.2207 c

2.4400 ± 0.0673 b

Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST)

  Alanine aminotransferase (IU/L)

35.4150 ± 3.4579 a

58.4950 ± 2.8626 c

49.3925 ± 2.0108 b

48.2525 ± 2.2658 b

45.3300 ± 3.3633 b

  Aspartate aminotransferase (IU/L)

96.6850 ± 2.4504 a

133.2475 ± 4.2493 c

116.5300 ± 3.5965 b

114.0350 ± 2.7041 b

110.6700 ± 2.7200 b

  1. HDL, High-density lipoprotein; LDL, low-density lipoprotein
  2. Data are presented as the mean of eight rats (n = 8 per group) ± SE. Values followed by different lowercase letters within the same column are significantly different among the groups at P < 0.05
  3. aSee Table 1
  4. b(Total cholesterol − HDL-cholesterol) − (triglyceride/5)
  5. c(Total cholesterol − HDL-cholesterol)/HDL-cholesterol
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Annals of Microbiology

ISSN: 1869-2044

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