Fig. S2From: Improvement of the ability to produce spinosad in Saccharopolyspora spinosa through the acquisition of drug resistance and genome shufflingGrowth trend of spinosad production by genome shuffling and drug resistance. Ery-13, Ery-70, Ery-150: strains that have erythromycin resistance in drug resistance screening. Neo-25, Neo-42, Neo-127: strains that have neomycin resistance in drug resistance screening. Ery-13 and Neo-127 strains were used as the starting strains for genome shuffling. EN1: strains generated from the first round of genome shuffling. EN2: strains generated from the second round of genome shuffling. EN3: strains generated from the third round of genome shuffling. EN4: strains generated from the fourth round of genome shuffling. The best isolate after four rounds of genome shuffling (EN4-33) exhibited a spinosad yield of 332 μg/ml. Bar represents mean spinosad yield with less than 15 % standard deviation (GIF 517 kb)Back to article page