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Fig. 6 | Annals of Microbiology

Fig. 6

From: Gene modification of Escherichia coli and incorporation of process control to decrease acetate accumulation and increase ʟ-tryptophan production

Fig. 6

The metabolic flux distribution of ʟ-tryptophan biosynthesis under different culture conditions during the later fermentation periods (30–38 h). ʟ-Tryptophan production with different culture conditions are shown as: BCTRP with original culture conditions (first value); BCTRPG with original culture conditions (second value); BCTRPG with 30% DO (third value); BCTRPG with 30% DO and glucose feedback feeding (fourth value); and BCTRPG with 30% DO, glucose feedback feeding, and sequential pH adjustment (fifth value). Metabolite abbreviations: Glc6P (glucose 6-phosphate), F6P (fructose 6-phosphate), GAP (glyceraldehyde 3-phosphate), P3G (3-phosphoglycerate), PEP (phosphoenolpyruvate), Pyr (pyruvate), AcCoA (acetyl coenzyme A), Ru5P (ribulose 5-phosphate), X5P (xylulose 5-phosphate), S7P (sedoheptulose 7-phosphate), E4P (erythrose 4-phosphate), Cho (chorismate), PRPP (5-phosphoribosyl pyrophosphate), OAA (oxaloacetate), αKG (α-ketoglutarate), Gln (glutamine), Glu (glutamate), and Ser (serine)

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Annals of Microbiology

ISSN: 1869-2044

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