Table 4 IC50 values of crude extracts of bacterial strains isolated from marine sponge Theonella swinhoei against cancer cell lines MCF-7, MDA-MB-231, and T47-D from breast tumors, MOLT-4 and K-562 from leukemia, and DLD-1 and HCT-116 from colorectal cancer using the MTT method
Isolate | IC50 (μg/ml) | ||||||
|---|---|---|---|---|---|---|---|
K-562 | Molt 4 | DLD-1 | T47-D | HCT-116 | MCF-7 | MDA-MB-231 | |
AIAC10-11 (A) | < 1 | < 1 | 4.61 | 23.58 | – | 8.95 | 31.91 |
AIAC1-21 (A) | < 25 | < 25 | – | 3.08 | 9.96 | – | 1.02 |
GIC10-1 (A) | < 25 | < 25 | 11.81 | 3.51 | 21.19 | – | – |
GIC1-13 (A) | < 1 | < 1 | 24.73 | 18.7 | – | – | 3.57 |
M1C1-37 (A) | NA | 0.26 | 4.61 | 3.95 | 2.87 | 13.2 | 2.89 |
PYAC20-24 (A) | < 25 | < 25 | 1.13 | 23.58 | – | 8.95 | 31.91 |
PYAU1-1 (A) | < 15.625 | < 15.625 | 13.68 | 2.42 | 27.64 | 15.96 | 3.65 |
PYAN10-21 (B) | 16.04 | 0.67 | 0.05 | 0.57 | 12.19 | 0.52 | 0.88 |