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Table 1 Antimicrobial activity of extracts obtained from N. sphaerica at concentrations ranging from 128 to 0.25 μg/mL

From: Evaluation of in vitro alpha-glucosidase inhibitory, antimicrobial, and cytotoxic activities of secondary metabolites from the endophytic fungus, Nigrospora sphaerica, isolated from Helianthus annuus

Microorganisms

MIC/MBC or MFC (μg/mL)

BE

CE

CH

Vancomycin

Gentamicin

Clotrimazole

Amphotericin B

Bacteria

  Staphylococcus aureus ATCC25923

16/128

64/128

128/128

0.5/1

–

–

–

  Methicillin-resistant S. aureus (MRSA)

32/128

128/128

128/128

1/2

–

–

–

  Escherichia coli ATCC25922

–

–

–

0.25/1

–

–

–

  Pseudomonas aeruginosa ATCC27853

–

–

–

0.25/1

–

–

–

Yeast

  Candida albicans ATCC90028

62/128

128/128

64/128

–

–

–

0.25/1

  C. albicans NCPF3153

64/128

128/128

128/128

–

–

–

0.125/1

  Cryptococcus neoformans ATCC90112

64/128

128/128

128/128

–

–

–

0.25/1

  C. neoformans ATCC90113

128/128

128/128

128/128

–

–

–

0.25/1

Filamentous fungi

  Microsporum gypseum clinical isolate

–

–

–

–

–

1/32

–

  Talaromyces marneffei clinical isolate

4/16

128/128

–

–

–

–

0.25/2

  1. BE fermentation broth extracted with ethyl acetate, CE mycelia extracted with ethyl acetate, CH mycelia extracted with hexane